Revolutionizing Parkinson’s Disease Treatment: A Critical Analysis of Preclinical Models

More than 50 years have passed since the introduction of L-dopa in the palliative treatment of Parkinson’s disease. Despite its widespread use, L-dopa remains plagued by severe side effects, such as dyskinesia, after prolonged administration. The search for alternative therapies has led to numerous preclinical investigations based on endogenous neurotoxin models. However, these efforts have consistently failed to translate into successful clinical trials.

The scientific community remains largely unaware of these failures, and it is essential to redirect their focus towards potential therapeutics that can slow or halt the progression of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models provides a thorough analysis of preclinical models based on exogenous neurotoxins, highlighting their limitations and the need for alternative approaches.

This comprehensive book is an invaluable resource for neuroscientists, neurologists, and neuropharmacologists seeking to understand the intricacies of Parkinson’s disease. The discussion of newer preclinical models, their benefits, and the need for their implementation will greatly benefit researchers and clinicians alike.

In addition to its in-depth analysis of preclinical models, this book provides a solid foundation in dopamine metabolism, making it an excellent resource for students of neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine.

The book’s comprehensive coverage includes:

• Parkinson’s disease classification, pharmacological therapies, and non-motor and motor symptoms
• An in-depth analysis of preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed
• A review of genetic preclinical models based on genetic mutations and endogenous neurotoxins
• A proposed more physiological model directly related to the metabolism of dopaminergic neurons
• The basic concepts and mechanisms of dopamine metabolism

Published by Elsevier Science in June 2021, this book is an essential reading for anyone seeking to stay at the forefront of Parkinson’s disease research and treatment.

ISBN: 9780128221204, 9780128221587