Connectomic Deep Brain Stimulation: A Comprehensive Guide

Connectomic Deep Brain Stimulation (DBS) is a highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor, and Dystonia. This book, authored by Andreas Horn, delves into the impact of DBS on distributed brain networks, leveraging modern-day neuroimaging concepts and the connectomics of the brain.

The book poses several pertinent questions, including:

• Which cortical areas should DBS electrodes be connected to in order to generate the highest possible clinical improvement?
• Which connections should be avoided?
• Could these connectomic insights be used to better understand the mechanism of action of DBS?
• How can they be transferred to individual patients, and more?

This comprehensive guide is suitable for neuroscientists, neurologists, and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery.

Written to provide a “hands-on” approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery, this book includes:

• Preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation, and fiber-tracking approaches).
• References (key articles, books, and protocols) for additional detailed study.
• Data analysis boxes in each chapter to help with data interpretation.

Published by Elsevier Science in September 2021, this book is available in English and offers a wealth of information for those interested in the field of DBS and its applications in treating movement disorders.