Cell Transplantation and Gene Therapy in Neurodegenerative Disease: Advancements and Challenges

Edited by Emma Lane, Cheney Drew, and Mariah Lelos, Volume 166 of the International Review of Neurobiology series sheds light on the latest breakthroughs in cell transplantation and gene therapy for neurodegenerative diseases.

New Insights into Neurodegenerative Disease Treatment

This comprehensive volume presents 10 chapters, each written by an international board of experts, covering the challenges and opportunities in translating cell therapies into clinical practice. Some of the topics explored include:

• Translating cell therapy to Good Manufacturing Practice (GMP)
• Developing cell therapies for Huntington’s disease and retinal diseases
• Overcoming barriers to gene therapy in Huntington’s disease
• Technological advancements and challenges in gene therapy
• Modulating cell therapy for spinal cord injury treatment
• Developing glial cell therapy for ALS

Exploring New Frontiers in Cell and Gene Therapy

Additional chapters delve into the applications of cell and gene therapy in current animal models of Parkinson’s and Huntington’s disease, the role of biomaterials in supporting cell therapy, and the neurosurgical challenges of delivering cell and gene therapies.

The volume also covers neuroimaging’s potential in facilitating cell and gene therapy, considerations for clinical trial design, and the crucial role of patients in Advanced Therapy Medicinal Product (ATMP) development and trials.

With 324 pages of in-depth analysis and expert insights, this book is a valuable resource for researchers, clinicians, and students seeking to understand the latest developments in cell transplantation and gene therapy for neurodegenerative diseases.

Published by Academic Press, this 1st edition was released on November 30, 2022, and is available in English.