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Primary Central Nervous System Lymphoma (PCNSL) is a type of non-Hodgkin lymphoma that is exclusively found in the brain parenchyma, meninges, and/or spinal cord at the time of diagnosis. PCNSL is more common in immunocompetent patients than immunocompromised individuals.
PCNSL is typically an aggressive, diffuse large B-cell lymphoma with a median survival time of only a few weeks to months without treatment. The therapeutic options for PCNSL are limited due to the challenge of crossing the blood-brain barrier. However, if this barrier can be overcome, the chemosensitivity of PCNSL is high.
The rarity of PCNSL means that most studies are based on small patient numbers, limiting their conclusiveness. Despite these challenges, promising curative treatment approaches have been established in recent years, involving induction and consolidation therapy. These approaches have achieved high remission rates and multi-year progression-free survival.
This comprehensive monograph provides an up-to-date overview of PCNSL, covering all aspects of this complex disease. The book offers a compact and informative summary of the current knowledge on PCNSL, making it an essential resource for healthcare professionals and researchers.
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