Unraveling the Complexity of Huntington’s Disease: A Decade of Breakthroughs and Advances

Edited by renowned experts Gillian Bates, Sarah Tabrizi, and Lesley Jones, this comprehensive guide provides an in-depth exploration of the genetics and neurobiology of Huntington’s Disease, a devastating neurodegenerative disorder that has puzzled researchers for decades.

Since the identification of the Huntington’s Disease gene and its mutation nearly a decade ago, significant strides have been made in understanding the disorder. This extensively updated fourth edition of the Oxford Monographs on Medical Genetics Series presents cutting-edge research and fresh insights into the molecular basis of the disease, its brain pathology, and emerging therapeutic approaches.

Groundbreaking Research and Advances

• International experts delve into the latest findings on the HD mutation, including its role in brain degeneration and the development of transgenic animal models.
• New research on neurochemical studies and advances in neuropathology provide a deeper understanding of the disease’s molecular mechanisms.
• Clinical sections cover both neurological and psychiatric aspects, as well as new developments in therapy, offering valuable insights for clinicians and researchers.

This authoritative book serves as an invaluable resource for:

• Geneticists seeking to understand the complex genetics of Huntington’s Disease
• Psychiatrists and neurologists looking to stay abreast of the latest clinical developments
• Basic research workers in genetics and neurobiology interested in exploring new therapeutic approaches

With its comprehensive coverage and expert insights, this book is poised to become a seminal work in the field of Huntington’s Disease research, helping to drive further breakthroughs and accelerate the discovery of effective treatments.

Details: ISBN-13: 9780199929146, Publisher: Oxford University Press, Publication Date: April 17, 2014, Pages: 512