Jasper’s Basic Mechanisms of the Epilepsies, 4th Edition: A Comprehensive Guide to Epilepsy Research

Edited by renowned experts Jeffrey Noebels, Massimo Avoli, Michael Rogawski, Richard Olsen, and Antonio Delgado-Escueta, Jasper’s Basic Mechanisms of the Epilepsies, 4th Edition, is a seminal work in the field of epilepsy research.

The first volume of Basic Mechanisms of the Epilepsies (BME) was published in 1969 by H.H. Jasper, A.A. Ward, A. Pope, and H.H. Merritt, with the ultimate goal of seeking a “better understanding of the epilepsies and seeking more rational methods of their prevention and treatment.” Since then, every decade and a half, basic and clinical researchers in epilepsy have gathered to assess the progress made, accomplishments, and future directions of epilepsy research.

In 1999, the third volume of BME was named in honor of H.H. Jasper, and the fourth edition continues this legacy, featuring 90 comprehensive chapters that delve into the intricate mechanisms of epilepsy. This edition is the most ambitious yet, showcasing the significant expansion of our understanding of basic epilepsy mechanisms over the past four decades.

Unraveling the Complexity of Epilepsy Mechanisms

The book meticulously examines the interactions between neurons, synapses, and glia in the initiation, spread, and arrest of seizures. It delves into the mechanisms of excitability, synchronization, seizure susceptibility, and ultimately, epileptogenesis. Furthermore, it provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies, as well as exploring disease mechanisms of ion channelopathies and developmental epilepsy genes.

The fourth edition also explores the mechanisms of conditions of epilepsy comorbidities and, for the first time, describes the current efforts to translate discoveries in epilepsy disease mechanisms into new therapeutic strategies.

A Valuable Resource for Researchers and Clinicians

Jasper’s Basic Mechanisms of the Epilepsies, 4th Edition, is an indispensable resource for students, clinician scientists, and research scientists conducting laboratory-based experimental epilepsy research using cellular, brain slice, and animal models. It is also essential for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain structures, including the cortex, hippocampus, and thalamus.

As the “bible” of basic epilepsy research, this book holds practical importance for clinical neurologists and epileptologists, as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures, and repairs in the epilepsies converge and impact clinical care.

With 1264 pages of in-depth content, this edition is a testament to the dedication of the researchers and editors who have worked tirelessly to advance our understanding of epilepsy and improve patient care.

Book Details

ISBN-13: 9780199746545
Publisher: Oxford University Press, USA
Publication Date: June 29, 2012
Series: Contemporary Neurology Series , #80
Edition Number: 4