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By Ghulam Md Ashraf
The human brain comprises billions of neurons that communicate with each other through chemical messengers, known as neuroactive substances. These substances include neurotransmitters, neuromodulators, and neurohormones, which play a crucial role in maintaining the delicate balance of our neurological and behavioral systems.
While the terms neurotransmitter, neuromodulator, and neurohormone are often used interchangeably, it’s essential to understand their distinct functions and how they interact with each other. Any disruptions in the functioning of these neuroactive substances can lead to a wide range of diseases and disorders.
The brain is the ultimate control center that regulates all aspects of our body through neuronal communications mediated via various neurochemicals. Therefore, it’s no surprise that neurological and psychiatric disorders often result from a disturbed neurochemical balance.
The central nervous system is a complex organization with numerous neurotransmitter systems, each with multiple receptors. An imbalance of these systems can manifest as neurological or psychiatric disorders, such as epilepsy, Parkinson’s disease, Alzheimer’s disease, psychosis, depression, and many others.
Acetylcholine, noradrenaline, dopamine, and 5-HT are among the most critical neurotransmitters, playing a profound role in the pathogenesis of various neurological and psychiatric disorders in humans. Additionally, the involvement of proteins, peptides, and endogenous chemical compounds, such as neurotrophic factors and growth factors, cannot be overlooked.
Day by day, the number of people suffering from neurotransmitter imbalance is increasing, leading to a rise in mental health complaints. Factors such as stress, diet, genetics, and toxins like alcohol and nicotine contribute to this imbalance, making it essential to address the root cause of these issues.
This book aims to provide a comprehensive overview of the neurological diseases associated with neurochemical imbalances, offering readers a thorough understanding of neuronal signaling and related neurological disorders. The book will also delve into the status and future opportunities and challenges in this field, serving as a valuable resource for those seeking to understand the complexities of neurochemical balance.
Whether you’re a student, researcher, or healthcare professional, this book will provide a detailed account of neurotransmission, making it an invaluable study or high-yield revision aid.
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