Neurotoxicity of Halogenated Organic Compounds: A Comprehensive Review

Edited by Lucio G. Costa, Volume 10 of the Neurotoxicity of Halogenated Organic Compounds series provides an in-depth exploration of the health and environmental impacts of chlorinated, brominated, and fluorinated compounds.

Understanding Halogenated Organic Compounds

Halogenated Organic Compounds (HOCs) are a class of legacy and emerging contaminants that have been linked to a range of adverse health effects, including neurotoxicity. These compounds are found in various forms, including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and perfluoroalkyl substances (PFAS).

Key Topics Covered

• Perspective on Halogenated Organic Compounds: understanding the background, characteristics, and physicochemical properties of HOCs
• The Neurotoxicity of Polychlorinated Biphenyls (PCBs) and their effects on the neuroendocrine system
• Mechanisms of PCB Neurotoxicity: exploring the role of the aryl hydrocarbon receptor (AHR) and thyroid hormone receptor (THR) pathways
• Microbiome and the Neurotoxicity of Brominated Flame Retardants (BFRs): examining the impact of BFRs on the gut-brain axis
• Neurochemical Effects of Halogenated Organic Compounds: possible modes of action and structure-activity relationships

The Impact of Halogenated Organic Compounds on Human Health

The book covers the latest research on the epidemiological, behavioral, and neurochemical effects of HOCs, including their impact on human cohorts and animal models. The chapters also delve into the regulatory aspects of HOCs, providing insight into the current state of policy and future directions.

Key Takeaways

This comprehensive volume provides:

• The latest research on the neurotoxicity of HOCs, including epidemiological, behavioral, and neurochemical effects
• In-depth analysis of the neuroendocrine and neurochemical effects of PCBs, BFRs, and PFAS
• Regulatory insights and future directions for the management and mitigation of HOCs

Order your copy today to stay up-to-date on the latest research in the field of neurotoxicity and halogenated organic compounds.

Publication Details:

• Publisher: Elsevier Science
• Publication Date: October 26, 2023
• Language: English
• ISBN: 9780443133404 (hardcover), 9780443133411 (ebook)