Precision Medicine in Neurodegenerative Disorders: Revolutionizing the Approach to Brain Aging

Part Two, Volume 193 of the Handbook of Clinical Neurology, edited by Alberto J. Espay, addresses the crucial “how” in reconfiguring our approach to slow accelerated brain aging. This comprehensive book challenges conventional thinking, rethinking animal models used to test therapies and outlining progress in biological subtyping efforts.

Unraveling the Mechanisms of Disease Pathophysiology

The book delves into the intricate mechanisms of disease pathophysiology, including lysosomal, endosomal, mitochondrial, immune dysregulation, and inflammatory mechanisms. The role of microbiome in shaping disease is also explored, providing a deeper understanding of the complexities involved.

Precision Medicine: Matching Biology with Intervention

The volume expertly separates disease-modifying neurorescue and neurorestoration approaches, such as gene therapy and cell replacement therapy, from true precision medicine, where biology is matched with the mechanism of intervention of interest.

Emerging Advances in Diagnosis and Treatment

Specific chapters focus on the promise and challenges of extracellular vesicles for both diagnosis and treatment, the growing application of digital measures to evaluate clinical response, and the innovative design of adaptive clinical trials. Regulatory changes necessary to facilitate drug development for disease-modification purposes are also discussed.

Book Details:

Published by Elsevier, this 1st edition book was released on June 23, 2023. With 392 pages, it provides a comprehensive overview of precision medicine in neurodegenerative disorders. The language is English, and the ISBN numbers are ISBN-10: 0323855555 and ISBN-13: 978-0323855556.