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By Heba Mohamed Mansour, Mahmoud Mohamed Khattab, and Aiman Saad El-Khatib
Overexpression of receptor tyrosine kinases (RTKs) has been implicated in various diseases, including cancer. Growing evidence suggests that dysregulation of RTKs also plays a significant role in many neurodegenerative and psychiatric disorders.
This book provides a fundamental and pragmatic overview of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in the developing central nervous system (CNS), adult normal CNS, neurodegenerative, and psychiatric disorders.
The book also covers the structure, function, activation, and therapeutic potential of many growth factors, offering a comprehensive discussion of the results of pre-clinical and clinical studies of repositioning anti-cancer receptor tyrosine kinase inhibitors (RTKIs) and other promising protein kinase inhibitors in various neurodegenerative disorders, including:
Additionally, the book examines RTKIs and other protein kinase inhibitors in pre-clinical and clinical trials for psychiatric disorders, including:
Renowned experts in biology, pharmacology, neurology, psychiatry, and oncology contribute to this comprehensive review, providing insights into the obstacles and opportunities for the potential repositioning of kinase inhibitors in neurodegenerative and psychiatric disorders.
The book offers future directions for possible safe and effective targeted RTKIs and other protein kinase inhibitors that may be repositioned in various neurodegenerative and psychiatric disorders.
With 604 pages of in-depth information, this book is an invaluable resource for researchers, clinicians, and students seeking to understand the complex role of RTKs in health and disease.
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