Regenerative Nephrology: A Comprehensive Guide to Kidney Regeneration

Since the publication of the first edition in 2010, the field of Regenerative Nephrology has witnessed a surge in groundbreaking discoveries. This second edition, authored by Michael S. Goligorsky, delves into diverse topics such as the influence of age and gender on regenerative processes, mechanisms of premature cell senescence, and how intrinsic regenerative processes can be subverted by noxious stressors, leading to disease progression.

The book also explores novel mechanistic and engineering efforts aimed at recreating functional kidney components, cell reprogramming and reconditioning as emerging tools for future regenerative efforts, and the effects of various biologicals on kidney regeneration. These additions to the armamentarium of Regenerative Medicine and Nephrology have been integrated into the second edition.

Key Features of the Second Edition

A significant expansion of the section on induced pluripotent cells and their differentiation trajectories, providing insights into the potential therapeutic applications of these cells.

A new section dedicated to tissue engineering of the kidney, which will be of particular interest to nephrologists and urologists. This section delves into the latest advancements in the field and their potential implications for kidney disease treatment.

A comprehensive section focused on the causes of regenerative failure, with a special emphasis on recent discoveries related to senescent cells in kidney disease. This section also covers the pathologic effects of senescent cells, advents in senotherapies, and rejuvenation therapies.

A vastly expanded section on pharmacotherapies that promote kidney regeneration, including updates on clinical trials of engineered organs, manufacturing in regenerative medicine, and the smooth transition to clinical trials. This section also addresses some ethical issues related to these advancements.

With its comprehensive coverage of the latest research and advancements in Regenerative Nephrology, this book serves as an invaluable resource for researchers, clinicians, and students seeking to understand the complex interplay between kidney regeneration and disease.