The GnRH Neuron and its Control: A Comprehensive Guide

Introduction: The GnRH Neuron and its Control is a seminal work that delves into the developmental biology of GnRH neurons, encompassing their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation. This book also explores the hypothalamic mechanisms that control GnRH neurons in adulthood, generating pulsatile and surge modes of GnRH secretion throughout the major life stages, including aging.

Developmental Biology of GnRH Neurons

The book provides an in-depth analysis of the developmental biology of GnRH neurons, covering their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation. It offers insights into the hypothalamic mechanisms that control GnRH neurons in adulthood, generating pulsatile and surge modes of GnRH secretion throughout the major life stages, including aging.

Adult GnRH Neuron Function

The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying the function of the adult GnRH neuron are discussed in detail. The neuroendocrinology and cell biology governing the generation of both modes of GnRH release are also thoroughly examined.

Neurobiological Mechanisms and Circuitry

The book reviews the neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism. It covers the current and potential therapeutic approaches to regulating GnRH secretion and action, providing students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology.

Part of the Wiley-INF Masterclass in Neuroendocrinology Series

The GnRH Neuron and its Control is the fifth volume in the Wiley-INF Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation). This series aims to illustrate the highest standards and encourage the use of the latest technologies in basic and clinical research, hoping to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Publication Details: This book is a hardcover edition, comprising 536 pages, published by Wiley-Blackwell on May 7, 2018. It is available in English and measures 6.7 x 9.6 inches.