The GnRH Neuron and its Control: A Comprehensive Guide

The GnRH Neuron and its Control is a comprehensive guide that delves into the developmental biology of GnRH neurons. It covers their birth in the nasal placode of the early embryo, perinatal programming, and sexual differentiation. The book also explores the hypothalamic mechanisms that control GnRH neurons in adulthood, generating pulsatile and surge modes of GnRH secretion throughout the major life stages including aging.

Developmental Biology of GnRH Neurons

The developmental biology of GnRH neurons is a crucial aspect of the book. It discusses the birth of these neurons in the nasal placode of the early embryo, their perinatal programming, and sexual differentiation. This section provides readers with a deep understanding of how these neurons develop and mature.

Hypothalamic Mechanisms and Adult GnRH Neurons

The book also examines the hypothalamic mechanisms that control GnRH neurons in adulthood. It discusses how these mechanisms generate pulsatile and surge modes of GnRH secretion throughout the major life stages, including aging. This section is essential for understanding the role of GnRH neurons in adult life.

Morphology, Electrophysiology, and Signal Transduction Pathways

The morphology, electrophysiology, signal transduction pathways, transcriptional regulators, and genomics underlying the function of the adult GnRH neuron are discussed in detail. This section provides a comprehensive understanding of the biology and function of GnRH neurons.

Neuroendocrinology and Modulation of GnRH Neurons

The neurobiological mechanisms and circuitry responsible for the modulation of the activity of GnRH neurons by season, stress, nutrition, and metabolism are reviewed. This section is vital for understanding how external factors influence GnRH neurons.

Therapeutic Approaches and Future Directions

The book covers current and potential therapeutic approaches to regulating GnRH secretion and action. It also discusses future directions in the field of reproductive neuroendocrinology, providing insights into potential areas of research and development.

Filled with newly identified research and classical fundamental knowledge to GnRH biology, The GnRH Neuron and its Control aims to provide students, researchers, and practitioners with an in-depth understanding of reproductive neuroendocrinology. It is the fifth volume in the Masterclass in Neuroendocrinology Series, a co-publication between Wiley and the INF (International Neuroendocrine Federation) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology.