Advances in Cancer Research, Volume 150: Exploring Autophagy and Senescence in Cancer Therapy

Advances in Cancer Research, Volume 150, delves into the intricate relationship between autophagy and senescence in cancer therapy. This comprehensive volume provides insights into how these cellular responses influence tumor dormancy and disease recurrence.

Understanding Autophagy and Senescence

Autophagy and senescence are two distinct cellular processes that play crucial roles in maintaining cellular homeostasis. Autophagy is a natural process in which cells recycle and remove damaged or unnecessary parts. Senescence, on the other hand, is a state of permanent cell cycle arrest that can be triggered by various forms of cellular stress. Both processes have been implicated in cancer development and progression.

Converging Roles in Pathophysiology

The interplay between autophagy and senescence has significant implications for cancer treatment. While autophagy can promote cell survival by providing energy and building blocks for cellular renewal, senescence can limit the proliferative potential of cancer cells. This volume explores the complex relationship between these two processes and their impact on cancer pathophysiology.

Cellular Senescence and Tumor Promotion

Cellular senescence can paradoxically promote tumor growth by creating an inflammatory microenvironment that fosters the proliferation of nearby cancer cells. This volume discusses the role of the unfolded protein response, autophagy, and senescence in promoting tumor growth and disease progression.

Autophagy and Senescence in Cancer Stem Cells

Cancer stem cells are a subpopulation of cancer cells that possess the ability to self-renew and initiate tumor formation. Autophagy and senescence play critical roles in maintaining the stemness of these cells. This volume examines the interplay between autophagy, senescence, and cancer stem cells, providing insights into potential therapeutic strategies.

Targeting Autophagy and Senescence for Cancer Treatment

Given the complex roles of autophagy and senescence in cancer, targeting these processes could provide novel therapeutic strategies for cancer treatment. This volume explores the potential benefits and challenges of manipulating autophagy and senescence in cancer therapy.

Autophagy and PTEN in DNA Damage-Induced Senescence

PTEN is a tumor suppressor protein that regulates various cellular processes, including cell cycle arrest and apoptosis. This volume discusses the interplay between PTEN, autophagy, and senescence in response to DNA damage, highlighting potential therapeutic targets for cancer treatment.

mTOR as a Senescence Manipulation Target

The mTOR pathway is a key regulator of cellular metabolism and growth. Manipulating mTOR activity can influence both autophagy and senescence, providing a potential therapeutic strategy for cancer treatment. This volume examines the role of mTOR in regulating cellular responses to stress and its implications for cancer therapy.