Environmental Carcinogenesis: Uncovering the Mechanisms of Carcinogenic Metals

Edited by Max Costa, Volume 96 in the Advances in Pharmacology series delves into the world of carcinogenic metals, shedding light on their mechanisms of action and the impact on human health. This comprehensive volume explores the latest research on arsenic and chromate, two of the most potent carcinogenic metals.

Insights into the Mechanisms of Carcinogenicity

The book presents a collection of chapters that delve into the intricacies of carcinogenic metals, including:

• Breast cancer carcinogenesis by organophosphate pesticides
• Polyadenylation of Canonical histone H3.1 in Carcinogenesis
• Epigenomic reprogramming in iAs-mediated carcinogenesis
• MicroRNAs and epigenetic regulation in metal-induced angiogenesis and carcinogenesis
• Environmental epigenetics and new mechanistic markers of chemical exposure
• Arsenic carcinogenesis by inhibition of DNA repair
• Genetic and environmental reprogramming of the sarcoma epigenome
• Mechanism of chromate carcinogenesis by chromatin alterations

A Deeper Understanding of Arsenic and Chromate

The book also explores the specific roles of arsenic and chromate in carcinogenesis, including:

• Arsenic carcinogenesis and microRNAs
• Epigenetic mechanism of Cr(VI)-induced cell malignant transformation and tumorigenesis
• The dark side of NRF2 in arsenic carcinogenesis
• Chemical mechanisms of DNA damage by carcinogenic chromium(VI)

With 380 pages of in-depth research and analysis, this volume is a valuable resource for scientists, researchers, and medical professionals seeking to understand the complex mechanisms of carcinogenic metals.

Product Details:

• Publisher: Academic Press
• Edition: 1st edition
• Release Date: March 10, 2023
• Language: English
• Format: Hardcover
• Pages: 380
• ISBN-10: 0323997759
• ISBN-13: 978-0323997751