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Despite a decline in tobacco use, lung cancer remains the leading cause of cancer deaths worldwide, with non-small-cell lung cancer (NSCLC) accounting for approximately 80% of cases. However, with advances in medical technology and research, early detection and treatment have become more effective.
Annual low-dose CT screening of high-risk individuals has been shown to detect early-stage tumors, which can be successfully treated with a combination of surgery, radiotherapy, and chemotherapy. In some cases, targeted therapy may also be effective.
Most patients with NSCLC present with advanced or metastatic disease, making accurate diagnosis and staging crucial for guiding initial therapy. Molecular characteristics and performance status play a significant role in determining the best course of treatment.
Targeted therapies have significantly improved clinical outcomes for patients with specific genetic alterations. For those without targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefits. Additionally, oligometastatic disease and brain metastases require specialized treatment approaches.
This insightful guide provides a comprehensive overview of the latest developments in lung cancer diagnosis, treatment, and management. It is an essential resource for all health professionals and medical trainees working in this fast-moving field.
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