Understanding GPCR Signaling in Cancer: A Comprehensive Guide

GPCR Signaling in Cancer, Volume 145, is the latest release in the Advances in Cancer Research series, shedding light on the recent developments in the area of GPCRs and cancer biology. This volume comprises several chapters that delve into the role of GPCRs and their downstream effectors as case examples, highlighting their fundamental understanding and therapeutic potential in cancer.

Key Topics Covered

The book covers a range of topics, including:

• Role of GRKs and beta-arrestins in cancer: This chapter provides insights into the role of G protein-coupled receptor kinases (GRKs) and beta-arrestins in cancer development and progression.
• Atypical GPCRs in cancer: This section explores the role of atypical GPCRs in cancer biology, highlighting their unique characteristics and potential therapeutic applications.
• Role of a chemokine receptor (CCR) 5 in cancer: This chapter focuses on the role of CCR5 in cancer, discussing its implications for cancer therapy and potential drug targets.
• Targeting G protein-coupled receptors for therapeutics in cancer: This topic is covered extensively, providing an overview of the therapeutic potential of targeting GPCRs in cancer treatment.
• Emerging GPCR signaling pathways in cancer: This section delves into the emerging signaling pathways of GPCRs in cancer, highlighting new areas of research and potential therapeutic strategies.

Why This Book Matters

G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors that are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and are targeted by nearly one-third of the currently prescribed drugs, including anti-cancer therapeutics. As such, understanding GPCR signaling in cancer is crucial for the development of effective cancer treatments.

Target Audience

This book is designed for researchers, scientists, and oncologists interested in the latest concepts in GPCR signaling and their relevance to cancer biology. It provides new indications for anti-cancer therapeutic programs and includes sections on cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics.