GPCR Signaling in Cancer: A Comprehensive Guide

GPCR Signaling in Cancer, Volume 145, is the latest release in the Advances in Cancer Research series. This book highlights recent developments in the area of GPCRs and cancer biology. It covers several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential.

Key Topics Covered

The book includes chapters on the following topics:

• Role of GRKs and beta-arrestins in cancer
• Atypical GPCRs in cancer
• Role of a chemokine receptor (CCR) 5 in cancer
• Targeting G protein-coupled receptors for therapeutics in cancer
• Emerging GPCR signaling pathways in cancer

About G Protein-Coupled Receptors (GPCRs)

G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.

Why This Book Matters

Understanding GPCR signaling and its relevance to cancer biology is crucial for the development of new anti-cancer therapeutic programs. This book provides insights into cross-talk and signaling networks of GPCRs and effectors in molecular oncology and therapeutics.

Author

Arunkumar K. Shukla is a renowned author in the field of GPCRs and cancer biology. His work has significantly contributed to the understanding of GPCR signaling and its implications for cancer treatment.