Comprehensive Review of Heterogeneous Radiation: Clinical Applications and Biological Considerations

This authoritative textbook provides a multidisciplinary approach to understanding the physics of heterogeneous radiation, linking fundamental principles to clinical applications and biological considerations. The comprehensive review covers Spatially Fractionated Radiation Therapy (SFRT), a cutting-edge modality for treating bulky and advanced tumors.

Fundamental Principles and Techniques of SFRT

The book delves into the dosimetric properties of SFRT, planning methods, and documentation, providing a solid foundation for clinicians and researchers. It also explores various techniques, including:

• GRID collimator- and MLC-based GRID therapy
• 3D Lattice radiation therapy
• Flash radiation therapy
• Minibeam and microbeam therapy
• Proton beam GRID therapy

Clinical Applications and Patient Outcomes

The authors present the current status and results of clinical patient studies, highlighting the potential of SFRT to advance tumor management. The book also discusses clinical practice recommendations and standardized reporting metrics, providing valuable insights for healthcare professionals.

Biological Underpinnings and Radiobiological Understanding

The textbook reviews potential biological correlations and underpinnings that may challenge current radiobiological understanding of radiation response and therapy design parameters. This multidisciplinary understanding is crucial as the field of heterogeneous radiation rapidly advances in technological development and clinical investigation.

Additional Topics and Techniques

The book covers a range of topics, including:

• GRID and Lattice therapy plan evaluation and documentation
• Monte Carlo simulation techniques of SFRT
• Practical applications and procedures
• Biological correlations and potential biological underpinnings
• Immune phenomena in SFRT

Published by the Institute of Physics Publishing on June 29, 2023, this comprehensive textbook is an essential resource for clinicians, researchers, and students seeking to advance their knowledge of heterogeneous radiation and SFRT.

Language: English

ISBN: 9780750340441, 9780750340465