A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery

By renowned pharmacologist Terry P. Kenakin, the sixth edition of A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery offers the latest insights into the application of pharmacology in drug discovery. This comprehensive guide aims to equip readers with a deeper understanding of the complex and rapid changes in this field.

This edition has been reorganized for better flow and clarity, and includes material on new technologies for screening, such as virtual screening, DNA-encoded libraries, and fragment-based screening. It also features a major section on phenotypic (target-agnostic) screening for new leads and the determination of drug targets.

With full-color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such as mRNA, gene therapy, antibodies, and information on CRISPR and genomics.

This edition highlights changes surrounding the strategy of drug discovery, providing a comprehensive reference with advances in the methods involved in lead optimization and more effective drug discovery. It illustrates the application of rapid, inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data.

Includes test questions and answers to help reinforce understanding of key concepts.

Published by Elsevier Science, August 14, 2022, in English, ISBN: 9780323992893, 9780323992909.