Contemporary Accounts in Drug Discovery and Development

Author: Xianhai Huang

ISBN: 9781119627715, 9781119627852

Publication Date: March 11, 2022

Language: English

Genre: Science, Medicine, Pharmaceutical Science

Summary: Contemporary Accounts in Drug Discovery and Development is a comprehensive guide for medicinal chemists and pharmaceutical scientists. It provides a thorough understanding of the drug discovery process, from identifying unmet medical needs to determining biological targets, chemical library screening, lead identification, chemical optimization, preclinical studies, and clinical trials. This book aims to improve the success rate in drug discovery and development by offering insights into modern drug discovery principles and advances in technology.

Key Features:

• Case histories to engage readers and provide a practical understanding of the drug discovery and development process.
• Detailed biological rationale and background information for each drug, including drug design principles, SAR development, ADMET considerations, and clinical studies.
• Coverage of drug candidates that have passed Phase I clinical trials, featuring different modalities such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs.
• Application of new technologies in drug discovery, including DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP).

Target Audience:

• Medicinal chemists
• Organic chemists
• Pharmacologists
• Other scientists in drug research and process development
• Graduate students in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology
• Pharmaceutical industry labs
• Libraries

Why You Should Read This Book:

Contemporary Accounts in Drug Discovery and Development is an essential resource for anyone involved in the drug discovery and development process. It offers a comprehensive understanding of the principles, technologies, and strategies used in drug discovery, making it a valuable tool for improving success rates and advancing in the field.