Contemporary Accounts in Drug Discovery and Development: A Comprehensive Guide

By Xianhai Huang, this book provides a detailed guide for medicinal chemists and pharmaceutical scientists, offering insights into the drug discovery process and its complexities. It serves as a valuable resource for those seeking to improve their understanding of drug discovery principles and the latest advancements in technology.

Understanding the Drug Discovery Process

The drug discovery process is a lengthy and intricate journey that involves identifying unmet medical needs, determining biological targets, screening chemical libraries to identify leads, optimizing these leads, conducting preclinical studies, and finally, clinical trials. This process can take years to complete and relies heavily on the practitioner’s knowledge of chemistry and biology, as well as their experience in the field.

Improving Success Rates in Drug Discovery

Enhancing the success rate in drug discovery and development is crucial for advancement in the field. This can be achieved through a thorough understanding of drug discovery principles and the latest technological advancements. Contemporary Accounts in Drug Discovery and Development aims to provide drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process.

Key Features of the Book

Contemporary Accounts in Drug Discovery and Development offers a comprehensive overview of the drug discovery process, including:

• Case histories used as an engaging way of learning about the drug discovery/development process
• Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies
• The full history of individual marketed small molecule drugs
• Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs
• The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP)

Target Audience

Contemporary Accounts in Drug Discovery and Development is an essential resource for:

• Medicinal chemists
• Organic chemists
• Pharmacologists
• Other scientists in drug research and process development
• Graduate students in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology
• Pharmaceutical industry labs
• Libraries

Publication Details

Contemporary Accounts in Drug Discovery and Development was published by Wiley on March 11, 2022. The book is available in English and features ISBNs 9781119627715 and 9781119627852.