Current Drug Synthesis: A Comprehensive Guide to Modern Drug Discovery

Authored by renowned medicinal chemist Dr. Jie Jack Li, Current Drug Synthesis is the latest addition to the esteemed Drug Synthesis series. This book offers an in-depth exploration of the medicinal chemistry behind current drugs, shedding light on the cutting-edge science involved in their synthesis.

With contributions from 27 expert coauthors, Current Drug Synthesis demystifies the process of modern drug discovery for both industry practitioners and students. It captures the state-of-the-art techniques used to discover some of the most impactful medicines on the market today.

Covering Six Key Disease Areas

The book covers six different disease areas, including:

• Infectious Disease
• Cancer
• Cardiovascular and Metabolic Disease
• Central Nervous System
• Anti-Inflammatory Disease
• Miscellaneous

Each chapter delves into the background material on a relevant drug class or disease indication, as well as key aspects of drug discovery such as structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety.

Drugs for Infectious Diseases

Readers will find thorough introductions to drugs for infectious diseases, including:

• Relebactam
• Vaborbactam
• Baloxavir marboxil

Cancer-Treating Drugs

The book provides in-depth treatments of cancer-treating drugs, such as:

• Darolutamide
• Venetoclax
• Osimertinib

Central Nervous System Drugs

Comprehensive explorations of central nervous system drugs are also included, covering:

• Zuranolone
• Risdiplam

Computational Drug Discovery and Peptide Drugs

Finally, the book concludes with chapters on computational drug discovery and peptide drugs, offering insights into the future of drug discovery and development.

Current Drug Synthesis is an essential resource for medicinal, organic, synthetic, and process chemists. It will also be of great value to research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

Published by Wiley in September 2022, Current Drug Synthesis is available in English and features ISBNs 9781119847250 and 9781119847267.