Drug Disposition and Pharmacokinetics: A Comprehensive Guide

By Stephen H. Curry, this book is a leading reference in drug disposition and pharmacokinetics. It provides an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects.

What’s New in the Latest Edition

This new, fully-revised edition offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. It includes:

• A new introductory chapter
• New chapters covering monoclonal antibodies, the role of stereochemistry in drug disposition and pharmacokinetics, DMPK in non-human species, and the recent use of AI in drug development

Key Topics Covered

Readers will find thorough introductions to drug disposition, pharmacokinetics, and pharmacokinetic modeling, as well as in-depth treatments of the kinetics of drug elimination and the relationship between concentration and effect, including PKPD modeling. The book also covers:

• Comprehensive discussions of predictive pharmacokinetics and the disposition of biological molecules, including peptides and monoclonal antibodies
• Detailed examinations of the effects of sex, pregnancy, age, and disease, as well as drug monitoring in therapeutics and the use of AI in drug development and treatment

Who Should Read This Book

Perfect for professionals and researchers working with the scientific aspects of drug disposition in human and veterinary medicine, toxicology, and pharmacology. This book will earn a place in the libraries of students of senior-level courses in pharmacy.

ISBN: 9781119588436, 9781119589198