Advances in Drug Repurposing and Computational Drug Discovery

Drug repurposing is a process that involves identifying new pharmacological indications from existing drugs, failed drugs, investigational drugs, or FDA-approved drugs. This approach aims to apply these new uses in the treatment of diseases other than the drugs’ original intended therapeutic use. Computational techniques play a crucial role in discovery research, not only in the development of drugs from leads or existing drug molecules but also in the repurposing of existing drug candidates.

This book presents recent advances in drug repurposing and computational approaches for the discovery and development of drugs against certain difficult-to-treat and life-threatening diseases. Contributions from a global team of experts (academicians, scientists, and researchers) explore the sophisticated tools and techniques of drug repurposing and computational drug discovery. The book delivers valuable information on computational techniques, tools, and databases being utilized for drug repurposing and for identifying the uses of existing drug candidates on different emerging or deadly diseases.

Targeted Diseases

Drug repurposing and computational approaches addressed in the book target the discovery and development of drugs for microbial infections (bacterial, fungal, viral, COVID-19), parasitic diseases and neglected tropical diseases (NTDs), malignant diseases (cancer), inflammatory diseases, cardiovascular disorders, diabetes, and aging and neurological (CNS) disorders.

Challenges and Future Directions

The book also looks at the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs, offering perspectives for future directions.