Advances in Drug Repurposing and Computational Drug Discovery

Drug repurposing, also known as drug repositioning, is the process of identifying new uses for existing drugs, including those that are FDA-approved, investigational, or failed. This approach has gained significant attention in recent years due to its potential to accelerate the drug development process and provide new treatments for various diseases.

This book, edited by Mithun Rudrapal, presents the latest advances in drug repurposing and computational drug discovery. It features contributions from a global team of experts who share their insights on the sophisticated tools and techniques being used in this field. The book covers a wide range of topics, including computational techniques, databases, and the challenges and regulatory issues encountered in drug repurposing and computational drug discovery.

The book is divided into several sections, each focusing on a different aspect of drug repurposing and computational drug discovery. Some of the key areas covered include:

• Microbial Infections: This section explores the use of drug repurposing and computational approaches for the discovery and development of drugs against bacterial, fungal, viral, and COVID-19 infections.
• Parasitic Diseases and Neglected Tropical Diseases (NTDs): This section discusses the application of drug repurposing and computational drug discovery for the treatment of parasitic diseases and NTDs, which are often neglected and pose significant health challenges in developing countries.
• Malignant Diseases (Cancer): This section delves into the potential of drug repurposing and computational drug discovery for the development of new cancer treatments, highlighting the challenges and opportunities in this area.
• Inflammatory Diseases: This section examines the role of drug repurposing and computational approaches in the discovery and development of drugs for inflammatory diseases, which are a leading cause of morbidity and mortality worldwide.
• Cardiovascular Disorders: This section focuses on the application of drug repurposing and computational drug discovery for the treatment of cardiovascular disorders, which are among the leading causes of death globally.
• Diabetes: This section explores the potential of drug repurposing and computational drug discovery for the development of new treatments for diabetes, a growing health problem worldwide.
• Aging and Neurological (CNS) Disorders: This section discusses the use of drug repurposing and computational approaches for the discovery and development of drugs for aging-related and neurological disorders, which pose significant health challenges in an aging population.
• Challenges and Regulatory Issues: This section addresses the challenges and regulatory issues encountered in drug repurposing and computational drug discovery programs, providing insights into the future directions of this field.

Overall, this book provides a comprehensive overview of the latest advances in drug repurposing and computational drug discovery, highlighting the potential of these approaches to accelerate the development of new treatments for various diseases. It is an essential resource for researchers, scientists, and policymakers working in this field.