Drug Transporters: A Comprehensive Guide to Molecular Characterization and Role in Drug Disposition

Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition, is a comprehensive guide that provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. The book is authored by Guofeng You, a renowned expert in the field of drug transporters, and features contributions from an international panel of leading researchers.

Overview of Relevant Drug Transporters

The book is divided into two parts, with the first part providing a thorough overview of relevant drug transporters. It covers the fundamentals of drug transporters, including their role in drug disposition, and the principles of drug transport and associated techniques. This section is essential for understanding the basics of drug transporters and their implications for drug efficacy and safety.

Advances in Drug Transporter Science

The second part of the book details the advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. It also includes new chapters on in vitro-in vivo scale-up of drug transport activities, the ontogeny of drug transporters, the application of physiologically-based pharmacokinetic and pharmacodynamic modeling, and the use of transporters as therapeutic targets for diseases.

Key Features of the Third Edition

The updated and expanded third edition reflects the current state of the field and offers perspectives on future directions. It covers basic knowledge, clinical outcomes, and emerging discoveries in transporter science, providing up-to-date information on drug transporter families, mechanisms, and clinical implications. The book includes extensive references and numerous figures and tables throughout, making it an invaluable resource for researchers and students alike.

Target Audience

Drug Transporters: Molecular Characterization and Role in Drug Disposition, Third Edition, is suitable for novices and experienced researchers in the field of drug transporters and related areas of drug metabolism, pharmacokinetics, and pharmacodynamics. It is an excellent textbook for pharmacological or physiological science courses in drug/membrane transport and a valuable reference for academic or industrial scientists working in the transporter field.

With its comprehensive coverage of drug transporter fundamentals, principles, and techniques, this book is a must-have for anyone interested in understanding the role of drug transporters in drug disposition and their implications for drug development and therapy.