Privileged Structures in Drug Discovery: A Comprehensive Guide

Privileged structures play a pivotal role in the discovery of new drugs, particularly during the lead optimization stages of the drug discovery process. This comprehensive guide offers a detailed review of privileged structures from a medicinal chemistry perspective, including synthetic routes to these structures.

With an historical perspective on the topic, this text provides a practical compendium to privileged structures and offers an informed perspective on the future direction for the field. It describes up-to-date and state-of-the-art methods of organic synthesis that are of most interest, including benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry.

Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume:

• Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them.
• Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry.
• Details many of the recent developments in organic chemistry that prepare target molecules.
• Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures.

Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, this guide offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.

Product Details:

Hardcover: 560 pages

Publisher: Wiley; 1 edition (March 27, 2018)

Language: English

ISBN-10: 1118145666

ISBN-13: 978-1118145661

Product Dimensions: 8.7 x 1.3 x 10.8 inches