Understanding Insulin and Insulin Resistance: A Comprehensive Guide

Written in simple and clear language, this valuable resource is designed to provide an in-depth understanding of insulin and insulin resistance, perfect for a broad audience including biochemists, medical professionals, dentists, academics, physicians, and research scholars.

A Systematic Approach to Insulin and Insulin Resistance

The book is meticulously designed to portray topics in a flow from simple to complex, making it easy to comprehend the complex interplay of various factors in the initiation of insulin resistance. It extends its approach to biochemistry, physiology, and metabolism of insulin, covering the pathophysiology of insulin resistance, its effects on body tissues, and its analysis on insulin resistance syndrome.

Chronology of Diabetes Mellitus and Insulin Discovery

Get exhaustive and latest knowledge related to the chronology of diabetes mellitus, different phases in the discovery of insulin, contribution of several workers in the discovery of insulin, insulin structure, types of insulin, and the role of latest insulin delivery devices, including various transdermal insulin delivery devices and bionic pancreas in the management of diabetes mellitus.

Insulin Gene, Transcription, and Regulation

Dive into the world of insulin gene, its structure, and the role of insulin gene-variable number of tandem repeats. Explore the insulin two genes versus single gene system, the role of a wide array of promoters, transcription factors, hormones, and nutrients in the regulation of transcription of the insulin gene. Additionally, discover the dysregulation of insulin gene transcription by glucotoxicity, lipotoxicity, unfolded-protein response, and activating transcription factor-6.

Biogenesis of Insulin Granules and Intracellular Trafficking

Learn about the biogenesis of insulin granules, the role of SNARE proteins, SYNTAXIN, SNAP-25, and VAMP-2 in the intracellular trafficking and exocytosis of insulin granules.

Models of Capillary Blood Flow and Insulin Secretion

Understand the models of capillary blood flow in pancreatic islets, triggering pathway, amplifying pathway, and the role of nutrients, hormones, especially Malonyl-CoA/Long chain-Acyl-CoA pathway, glucagon-like peptide-1, cholecystokinin hormone, ghrelin hormone, insulinotropic and insulinostatic effects of noradrenaline, Sirtuin 1, and mechanistic target of Rapamycin (mTOR) in insulin secretion.

Insulin-Mediated Signaling Pathways and Metabolic Effects

Gain knowledge about insulin-mediated signaling pathways, the role of glucose transporters, sodium-glucose linked transporters, and coverage of several metabolic and physiological effects of insulin, including insulin-mediated RANKL/RANK/OPG axis in osteoclastogenesis and bone resorption.

Etiopathogenesis of Insulin Resistance

Delve into the etiopathogenesis of insulin resistance, covering a wide range of topics including the role of genetic polymorphisms, demographic factors, diseases, pro-inflammatory molecules, endoplasmic reticulum stress, and mitochondrial dysfunction in the pathogenesis of insulin resistance. Special emphasis is given to explain the implication of advanced glycation end-products in the pathogenesis of insulin resistance.

Insulin Resistance Syndrome and Clinical Knowledge

Get a comprehensive understanding of insulin resistance syndrome, its prevalence, and components. This book blends both theoretical and clinical knowledge related to insulin and insulin resistance, and insulin resistance syndrome in a single volume, eliminating the need to search through hundreds of journal articles.

This resource is a valuable “ONE STOP SHOP” for students, research scholars, academicians, and clinicians, providing a comprehensive understanding of insulin, insulin resistance, and insulin resistance syndrome.