Sample Sizes for Clinical Trials, Second Edition: A Comprehensive Guide

Sample Sizes for Clinical Trials, Second Edition, is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book, there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation.

Comprehensive Coverage of Sample Size Calculations

The book provides comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data. It covers superiority, equivalence, non-inferiority, bioequivalence, and precision objectives for both parallel group and crossover designs. This extensive coverage ensures that researchers have all the necessary tools to accurately calculate sample sizes for their clinical trials.

Real-Life Clinical Trials Examples

The book is motivated with examples of real-life clinical trials, showing how the calculations can be applied in practice. These examples help researchers understand how to apply the sample size calculations in their own research, making the book a valuable resource for both novice and experienced researchers.

New Edition Features

The new edition of the book is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single-arm trials. These additions make the book even more comprehensive and up-to-date, providing researchers with the latest information and techniques in sample size calculations.

A Valuable Resource for Researchers

The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.

With its comprehensive coverage, practical examples, and up-to-date information, Sample Sizes for Clinical Trials, Second Edition, is an essential resource for researchers looking to design and conduct successful clinical trials.