The Comprehensive Textbook of Ion Channels: A Reference Guide for Students and Researchers

Edited by Jie Zheng and Matthew C. Trudeau, this three-volume set provides an extensive reference source on ion channels, covering their structure, function, and role in human health and disease.

The Importance of Ion Channels

Ion channels are membrane proteins that play a crucial role in controlling the electrical properties of neurons and cardiac cells, mediating sensory stimuli detection and response, and regulating the response to physical stimuli. They are essential for maintaining basic salt balance and homeostasis in non-excitable tissues.

Ion channels are located at the surface membrane of cells, enabling them to communicate with the environment, and at the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Their dysfunction is implicated in various human diseases, making them important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain, and other clinical applications.

Volume II: Ion Channel Taxonomy and Families

The second volume of this comprehensive textbook covers ion channel taxonomy, featuring extensive coverage of major ion channel families. It delves into the physiological role, structural components, gating mechanisms, biophysics, permeation, and selectivity of these channels, as well as their regulation, pharmacology, and roles in disease mechanisms.

Some of the ion channels covered in this volume include:

• Voltage-activated sodium, calcium, and potassium channels
• Inward-rectifier and two-pore domain potassium channels
• Calcium-activated potassium channels
• Cyclic nucleotide-gated channels
• Pacemaker ion channels
• Chloride channels
• Ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA, and glycine
• Acid-sensing channels
• P2X receptors
• TRP channels
• Store-operated channels
• Pressure-activated piezo channels
• Ryanodine receptors
• Proton channels

A Valuable Resource for Students, Instructors, and Researchers

The Textbook of Ion Channels provides an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, and a modern guide to the properties of major ion channel families. It also includes coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Publisher: CRC Press
Publication Date: June 28, 2023
Language: English